Metabolite Analysis of 11C Fatty Acids
| Time | 1-11C-PA (%) | 17-11C-HDA (%) | |||||
|---|---|---|---|---|---|---|---|
| Arterial | Coronary sinus | Arterial | Coronary sinus | ||||
| Normal | |||||||
| 1 | 96 ± 1 | 96 ± 1 | 97 ± 1 | 99 ± 1 | |||
| 5 | 94 ± 2 | 77 ± 2 | 97 ± 1 | 98 ± 3 | |||
| 10 | 89 ± 1 | 46 ± 3 | 97 ± 1 | 89 ± 2 | |||
| 20 | 65 ± 11 | 47 ± 11 | 92 ± 10 | 65 ± 14 | |||
| Dobutamine | |||||||
|---|---|---|---|---|---|---|---|
| 1 | 90 | 85 | 92 | 91 | |||
| 5 | 89 | 62 | 88 | 75 | |||
| 10 | 80 | 47 | 83 | 59 | |||
| 20 | 69 | 41 | 76 | 55 | |||
1-11C-PA = 1-11C-palmitate.
Percentage of radiotracer is amount of radioactivity remaining after acidification of sodium bicarbonate sample and sparging with nitrogen gas divided by total amount of radioactivity in equal-sized sample. All blood samples were corrected for decay and normalized to 1 g of blood.