TABLE 1

MBF Determined by ¹⁵O-H₂O PET and *Cu-ATSM Retention as Shown by Monoexponential Analysis (1/k_mono) and Kinetic Modeling (1/k₄) for Protocol I

Dog no.	Baseline flow (mL · min⁻¹ · g⁻¹)	Hypoxic flow (mL · min⁻¹ · g⁻¹)	Flow ratio	Mean retention
								Baseline			Hypoxic tissue
								1/k_mono (min)	1/k₄ (min)	1/k_mono (min)	1/k₄ (min)
1	1.18 ± 0.06	8.39 ± 0.32	7.09	10.75 ± 0.46	2.84 ± 0.83	>100	18.35 ± 8.62
2	0.42 ± 0.04	2.99 ± 0.09	7.12	15.70 ± 1.23	2.63 ± 1.11	36.63 ± 19.05	4.11 ± 1.53
3	0.51 ± 0.02	3.43 ± 0.39	6.78	17.39 ± 0.21	8.70 ± 2.48	27.62 ± 13.74	34.48 ± 4.52
Mean ± SD	0.70 ± 0.42	4.94 ± 3.00*	7.00 ± 0.19	14.61 ± 3.45	4.72 ± 3.44	54.75 ± 39.45	19.98 ± 15.19

↵* P < 0.0001 hypoxia vs. baseline.