TABLE 3

Biodistribution of ¹²⁵I-Radiolabeled mAbs in CEA Transgenic Mice Bearing CEA-Transfected Tumors

Tissue	mPR1A3					IC
Tissue		4 h	24 h	48 h	4 h	24 h	48 h
%ID per organ*
Spleen	0.43 ± 0.08	0.21 ± 0.03	0.16 ± 0.06	0.55 ± 0.15	0.61 ± 0.73	0.29 ± 0.14
Kidney	1.42 ± 0.30	0.74 ± 0.15	0.58 ± 0.18	1.78 ± 0.26	1.15 ± 0.44	1.05 ± 0.38
Intestines	8.22 ± 1.56	7.74 ± 2.11^†	6.59 ± 1.57^†	6.04 ± 1.25	3.70 ± 1.27	2.99 ± 1.19
Stomach	1.34 ± 0.24	0.80 ± 0.17	0.54 ± 0.07	2.28 ± 0.64	1.16 ± 0.35	0.92 ± 0.31
Liver	9.49 ± 0.92	4.33 ± 2.21	2.55 ± 0.72	8.97 ± 1.59	4.54 ± 1.66	4.29 ± 1.85
%ID/g*
Blood	28.87 ± 5.57	12.07 ± 2.25	10.25 ± 2.04	34.82 ± 7.13	21.04 ± 11.45	19.80 ± 6.36
Muscle	0.75 ± 0.11	0.92 ± 0.18	0.82 ± 0.25	1.11 ± 0.26	1.31 ± 0.30	1.67 ± 0.91
Bone	1.84 ± 0.14	1.56 ± 0.20	1.12 ± 0.26	2.47 ± 0.52	2.04 ± 0.55	2.22 ± 0.89
Tumor	35.26 ± 7.92^†	50.43 ± 11.80^†	46.60 ± 9.39^†	12.07 ± 2.67	8.89 ± 4.67	10.42 ± 3.19

↵* Mean (n = 4) ± SD.
↵^† Statistically significant difference (P < 0.05) between mPR1A3 and IC antibody.