Biodistribution of 125I-Radiolabeled mAbs in Wild-Type C57BL/6 Mice
| Tissue | mPR1A3 | IC | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 4 h | 24 h | 48 h | 4 h | 24 h | 48 h | |||||
| %ID per organ* | ||||||||||
| Spleen | 0.41 ± 0.07 | 0.28 ± 0.04 | 0.22 ± 0.02 | 0.38 ± 0.11 | 0.30 ± 0.02 | 0.25 ± 0.03 | ||||
| Kidney | 1.43 ± 0.24 | 1.05 ± 0.09 | 0.81 ± 0.07 | 1.43 ± 0.18 | 1.08 ± 0.02 | 1.00 ± 0.13 | ||||
| Intestines | 5.44 ± 0.51 | 3.11 ± 0.36 | 2.54 ± 0.14 | 4.88 ± 0.80 | 3.18 ± 0.05 | 2.91 ± 0.29 | ||||
| Stomach | 1.37 ± 0.24 | 0.42 ± 0.06 | 0.36 ± 0.04 | 1.01 ± 0.26 | 0.59 ± 0.16 | 0.43 ± 0.04 | ||||
| Liver | 6.98 ± 0.96 | 4.80 ± 0.69 | 3.81 ± 0.40 | 6.19 ± 0.72 | 4.45 ± 0.34 | 4.13 ± 0.54 | ||||
| %ID/g* | ||||||||||
| Blood | 24.73 ± 5.03 | 14.55 ± 1.33 | 13.21 ± 1.38 | 26.43 ± 6.49 | 15.16 ± 2.14 | 14.41 ± 2.26 | ||||
| Muscle | 1.40 ± 1.21 | 0.93 ± 0.22 | 0.94 ± 0.12 | 0.65 ± 0.13 | 0.74 ± 0.47 | 1.17 ± 0.26 | ||||
| Bone | 1.76 ± 0.37 | 1.49 ± 0.79 | 1.26 ± 0.07 | 1.30 ± 0.22 | 1.41 ± 0.25 | 1.38 ± 0.17 | ||||
↵* Mean (n = 4) ± SD.
There were no statistically significant differences in tissue distribution of the 2 antibodies.