TABLE 1

Values for IQ and Model Terms for 11C-l-Deprenyl (H) and 11C-l-Deprenyl-D2 (D) Calculated Using 3-Compartment Model

OrganIQ* (mL/min/g)K1k2k3λk3*k3/k2
Heart (H)0.43 ± 0.080.65 ± 0.130.22 ± 0.060.49 ± 0.161.47 ± 0.412.19 ± 0.36
Heart (D)0.23 ± 0.050.65 ± 0.230.26 ± 0.050.16 ± 0.0130.39 ± 0.060.65 ± 0.14
Lungs (H)0.095 ± 0.022.74 ± 1.600.84 ± 0.410.14 ± 0.0260.45 ± 0.0930.21 ± 0.10
Lungs (D)0.032 ± 0.00652.51 ± 0.720.77 ± 0.250.042 ± 0.0100.141 ± 0.0360.064 ± 0.035
Kidneys (H)1.06 ± 0.142.17 ± 0.320.40 ± 0.170.48 ± 0.152.76 ± 0.341.25 ± 0.23
Kidneys (D)0.4 ± 0.111.61 ± 0.220.33 ± 0.160.11 ± 0.0470.56 ± 0.130.35 ± 0.07
Spleen (H)0.111 ± 0.0121.71 ± 0.640.44 ± 0.160.045 ± 0.0070.172 ± 0.020.112 ± 0.042
Spleen (D)0.061 ± 0.0151.93 ± 0.610.47 ± 0.130.018 ± 0.0040.072 ± 0.020.037 ± 0.007
Liver§ (H)0.46 ± 0.12
Liver§ (D)0.32 ± 0.06
  • * D significantly smaller than H (P < 0.002).

  • Not significant except for kidneys, where K1 (H) > K1 (D); P = 0.04.

  • D significantly smaller than H (P < 0.01).

  • § Model terms other than IQ could not be calculated for liver.