Comparative Biodistribution of Coinjected 86Y-3S193 and 111In-3S193
Tissue | %ID/g 86Y | %ID/g 111In | Ratio 86Y/111In | |||
---|---|---|---|---|---|---|
Day 2 | Day 4 | Day 2 | Day 4 | Day 2 | Day 4 | |
Tumor | 29.8 ± 6.2 | 31.1 ± 3.6 | 29.1 ± 5.8 | 26.4 ± 2.4 | 1.03 ± 0.09 | 1.18 ± 0.11 |
Blood | 13.8 ± 2.2 | 8.2 ± 1.4 | 13.1 ± 2.2 | 7.9 ± 1.4 | 1.05 ± 0.03 | 1.05 ± 0.03 |
Lungs | 7.1 ± 1.3 | 6.2 ± 3.3 | 6.8 ± 1.3 | 6.0 ± 3.4 | 1.04 ± 0.02 | 1.05 ± 0.09 |
Liver | 6.2 ± 1.2 | 4.0 ± 1.4 | 5.5 ± 1.0 | 3.0 ± 0.9 | 1.14 ± 0.06 | 1.33 ± 0.19 |
Spleen | 3.4 ± 0.9 | 3.1 ± 0.3 | 3.6 ± 1.8 | 2.4 ± 0.3 | 1.01 ± 0.24 | 1.31 ± 0.19 |
Kidney | 5.9 ± 0.5 | 4.8 ± 0.2 | 5.1 ± 0.5 | 3.7 ± 0.7 | 1.16 ± 0.05 | 1.32 ± 0.19 |
Stomach | 2.6 ± 0.4 | 1.5 ± 0.5 | 2.3 ± 0.4 | 1.2 ± 0.3 | 1.15 ± 0.04 | 1.22 ± 0.16 |
Muscle | 1.0 ± 0.2 | 0.6 ± 0.1 | 1.0 ± 0.1 | 0.6 ± 0.1 | 1.00 ± 0.02 | 0.94 ± 0.11 |
Bone | 1.7 ± 0.3 | 1.7 ± 0.4 | 1.9 ± 0.4 | 1.4 ± 0.4 | 0.91 ± 0.04 | 1.20 ± 0.16 |
Data represent mean ± SD (n = 5).