TABLE 1

Biodistribution of Radiolabel (%ID/g) 2 Hours After Injection of Bivalent Radiolabeled Chelate

Tissue111In-diDTPA99mTc-diDTPA
Blood0.27 ± 0.030.23 ± 0.03
Muscle0.04 ± 0.010.07 ± 0.02*
Abscess0.34 ± 0.070.29 ± 0.13
Lung0.25 ± 0.040.36 ± 0.02*
Spleen0.40 ± 0.040.13 ± 0.03*
Kidney2.56 ± 0.241.69 ± 0.16†
Liver0.69 ± 0.030.22 ± 0.01*
Intestine0.25 ± 0.050.22 ± 0.05

  • Two groups of rats (n = 5) received DTIn-1 (t = 0 h, 2 nmol per rat). BSA-DTPA-In (t = 4 h, 1 nmol per rat) and radiolabeled bivalent chelate (t = 4 hr 5 min, 40 pmol per rat) were injected. Radiolabel biodistribution was determined 2 h after injection of radiolabel.

  • ↵* P = 0.008.

  • ↵† P = 0.02.