TABLE 1

Biodistribution of [¹⁸F]FETNIM in Rats Bearing DMBA-Induced Mammary Tumors

Tissue	15 min (n = 3)	30 min (n = 3)	60 min (n = 4)	120 min (n = 7)	240 min (n = 3)
Blood	0.325 ± 0.056	0.333 ± 0.056	0.206 ± 0.004	0.099 ± 0.024	0.053 ± 0.009
Plasma	0.313 ± 0.064	0.310 ± 0.047	0.155 ± 0.015*	0.080 ± 0.003^†	0.030 ± 0.007
Heart	0.338 ± 0.084	0.359 ± 0.057	0.246 ± 0.011	0.134 ± 0.032	0.071 ± 0.010
Lung	0.357 ± 0.056	0.360 ± 0.053	0.246 ± 0.014	0.113 ± 0.028	0.057 ± 0.008
Liver	0.400 ± 0.100	0.478 ± 0.091	0.322 ± 0.011	0.168 ± 0.046	0.142 ± 0.043
Spleen	0.329 ± 0.088	0.338 ± 0.061	0.213 ± 0.007	0.102 ± 0.023	0.054 ± 0.010
Kidney	0.737 ± 0.069	1.200 ± 0.450	0.504 ± 0.024	0.397 ± 0.092	0.231 ± 0.041
Bladder	2.10 ± 1.70	1.67 ± 0.89	0.90 ± 0.29	0.73 ± 0.71	NA
Urine	35 ± 11^‡	NA	NA	14 ± 5^§	18 ± 9
Adrenal gland	0.379 ± 0.074	0.480 ± 0.130	0.386 ± 0.094	0.177 ± 0.054	0.080 ± 0.002
Pancreas	0.246 ± 0.097	0.336 ± 0.059	0.186 ± 0.015	0.103 ± 0.022	0.063 ± 0.012
Intestine	0.330 ± 0.110	0.370 ± 0.065	0.360 ± 0.100	0.230 ± 0.150	0.129 ± 0.018
Stomach	0.320 ± 0.130	0.328 ± 0.038	0.370 ± 0.180	0.146 ± 0.036	NA
Fat (subcutaneous)	0.045 ± 0.012	0.043 ± 0.015	0.035 ± 0.010	0.013 ± 0.004	0.010 ± 0.006
Muscle	0.263 ± 0.065	0.345 ± 0.048	0.242 ± 0.009	0.116 ± 0.023	0.061 ± 0.011
Ovary	0.400 ± 0.120	0.418 ± 0.085	0.255 ± 0.023	0.123 ± 0.021	NA
Bone (skull)	0.054 ± 0.016	0.071 ± 0.009	0.058 ± 0.007	0.087 ± 0.052	0.025 ± 0.003
Marrow	0.480 ± 0.150	0.630 ± 0.270	0.372 ± 0.067	0.119 ± 0.038	NA
Cerebellum	0.069 ± 0.029	0.103 ± 0.024	0.094 ± 0.016	0.063 ± 0.009	0.045 ± 0.004
Tumor	0.480 ± 0.10*	0.383 ± 0.096^‡	0.239 ± 0.037^§	0.178 ± 0.046^∥	0.087 ± 0.043^¶

↵* n = 2.
↵† n = 3.
↵‡ n = 5.
↵§ n = 6.
↵∥ n = 23.
↵¶ n = 21.
NA = not available.
Data are mean ± SD %ID/g.