Parameter | Baseline | Stenosis | Occlusion | Reperfusion | Peak ATL-146e |
---|---|---|---|---|---|
Group 1 (no residual stenosis; n = 4) | |||||
Heart rate (bpm) | 118 ± 8 | — | 116 ± 9 | 104 ± 7 | 126 ± 5* |
MAP (mm Hg) | 89 ± 2 | — | 89 ± 3 | 94 ± 2 | 87 ± 2* |
LAP (mm Hg) | 6 ± 0 | — | 8 ± 0 | 7 ± 1 | 7 ± 0 |
dP/dt (mm Hg/s) | 1,858 ± 80 | — | 1,682 ± 107 | 1,675 ± 112 | 2,448 ± 60† |
LAD flow (mL/min) | 30 ± 4 | — | 0 ± 0† | 27 ± 4 | 62 ± 6‡ |
LAD wall thickening (%) | 26 ± 4 | — | −6 ± 2† | −7 ± 1† | −1 ± 3† |
LCx flow (mL/min) | 33 ± 5 | — | 37 ± 6 | 23 ± 2 | 100 ± 21‡ |
Group 2 (residual critical stenosis; n = 8) | |||||
Heart rate (bpm) | 124 ± 6 | 119 ± 6 | 128 ± 5 | 119 ± 5 | 126 ± 5‡ |
MAP (mm Hg) | 94 ± 3 | 93 ± 4 | 92 ± 3 | 96 ± 3 | 89 ± 3‡ |
LAP (mm Hg) | 7 ± 0 | 7 ± 0 | 8 ± 1 | 7 ± 1 | 8 ± 1 |
dP/dt (mm Hg/s) | 1,847 ± 70 | 1,840 ± 91 | 1,866 ± 73 | 1,746 ± 52 | 2,272 ± 83† |
LAD flow (mL/min) | 26 ± 3 | 25 ± 5 | 0 ± 0† | 17 ± 2 | 20 ± 2 |
LAD wall thickening (%) | 24 ± 2 | 21 ± 3 | −8 ± 1† | −7 ± 1† | −4 ± 1† |
LCx flow (mL/min) | 34 ± 4 | 33 ± 5 | 36 ± 5 | 32 ± 4 | 102 ± 14‡ |
↵* P < 0.05 vs. reperfusion.
↵† P < 0.01 vs. baseline.
↵‡ P < 0.01 vs. reperfusion.
Reperfusion = 165 min after reperfusion; MAP = mean arterial pressure; LAP = left atrial pressure; dP/dt = peak-positive first derivative of left ventricular pressure with respect to time.
Values are expressed as mean ± SEM.