TABLE 1

Hemodynamic Parameters

ParameterBaselineStenosisOcclusionReperfusionPeak ATL-146e
Group 1 (no residual stenosis; n = 4)
 Heart rate (bpm)118 ± 8116 ± 9104 ± 7126 ± 5*
 MAP (mm Hg)89 ± 289 ± 394 ± 287 ± 2*
 LAP (mm Hg)6 ± 08 ± 07 ± 17 ± 0
 dP/dt (mm Hg/s)1,858 ± 801,682 ± 1071,675 ± 1122,448 ± 60
 LAD flow (mL/min)30 ± 40 ± 027 ± 462 ± 6
 LAD wall thickening (%)26 ± 4−6 ± 2−7 ± 1−1 ± 3
 LCx flow (mL/min)33 ± 537 ± 623 ± 2100 ± 21
Group 2 (residual critical stenosis; n = 8)
 Heart rate (bpm)124 ± 6119 ± 6128 ± 5119 ± 5126 ± 5
 MAP (mm Hg)94 ± 393 ± 492 ± 396 ± 389 ± 3
 LAP (mm Hg)7 ± 07 ± 08 ± 17 ± 18 ± 1
 dP/dt (mm Hg/s)1,847 ± 701,840 ± 911,866 ± 731,746 ± 522,272 ± 83
 LAD flow (mL/min)26 ± 325 ± 50 ± 017 ± 220 ± 2
 LAD wall thickening (%)24 ± 221 ± 3−8 ± 1−7 ± 1−4 ± 1
 LCx flow (mL/min)34 ± 433 ± 536 ± 532 ± 4102 ± 14
  • * P < 0.05 vs. reperfusion.

  • P < 0.01 vs. baseline.

  • P < 0.01 vs. reperfusion.

  • Reperfusion = 165 min after reperfusion; MAP = mean arterial pressure; LAP = left atrial pressure; dP/dt = peak-positive first derivative of left ventricular pressure with respect to time.

  • Values are expressed as mean ± SEM.