TABLE 4

In Vitro Metabolism of [14C]Acetate by Human Tumors

Tumor typeTumor sampleIncubation time (min)Percentage of total 14C in acid extract
Unmetabolized [14C]acetateAcidic + any neutral metabolitesAmino acids + any basic metabolites
Glioblastoma11010123
20631229
210761016
20202552
310371751
20201759
Meningioma110582224
40412627
210423029
20223547
310112960
20123058
  • Protein content of acid-extracted slices was 0.06–1.2 mg per sample. Recovery of 14C in fractions of acid extract was 101% ± 4%.