Glucose Use and Acetate Uptake in Tumors and Rat Brain Tissue In Vivo
| Brain region | Glucose use (μmol/100 g/min) | Net acetate uptake (mL/100 g/ min) |
|---|---|---|
| Rat C6 glioma | 111.0 ± 34.0* | 9.9 ± 2.1† |
| Contralateral brain tissue | 81.0 ± 5.0 | 3.9 ± 1.0 |
| Tumor/contralateral tissue | 1.4 ± 0.5 | 2.3 ± 0.3‡ |
| Human U-373 glioblastoma/astrocytoma | 112.0 ± 27.0* | 4.2 ± 0.1† |
| Contralateral brain tissue | 86.0 ± 11.0 | 2.8 ± 0.5 |
| Tumor/contralateral tissue | 1.3 ± 0.2 | 1.5 ± 0.2 |
| Rat gray matter§ | ||
| Frontal cortex | ||
| Right | 82.4 ± 7.4 | 4.8 ± 0.7 |
| Left | 77.3 ± 6.5 | 6.9 ± 2.0 |
| Sensorimotor cortex | ||
| Right | 84.4 ± 7.8 | 4.6 ± 1.2 |
| Left | 75.4 ± 3.7 | 4.3 ± 1.4 |
| Caudate nucleus | ||
| Right | 83.6 ± 8.5 | 3.3 ± 0.4 |
| Left | 76.6 ± 9.6 | 3.7 ± 0.8 |
| Sensory cortex | ||
| Right | 87.6 ± 7.5 | 4.2 ± 0.8 |
| Left | 87.5 ± 7.9 | 4.1 ± 0.9 |
| Rat white matter§ | ||
| Forceps minor corpus callosum | ||
| Right | 35.6 ± 2.8 | 2.2 ± 0.6 |
| Left | 35.5 ± 2.3 | 2.3 ± 0.2 |
| Genu of corpus callosum | ||
| Right | 35.2 ± 2.4 | 2.5 ± 0.5 |
| Left | 32.0 ± 1.2 | 2.3 ± 0.4 |
↵* P < 0.09 vs. contralateral tissue.
↵† P < 0.005 vs. contralateral tissue.
↵‡ P < 0.05 vs. deoxyglucose tumor-to-tissue ratio.
↵§ Data are from rats implanted with C6 tumors.
Data are mean ± SD (C6 tumors: n = 6 for glucose use, n = 7 for acetate uptake; U-373 tumors: n = 4 per group for glucose use and acetate uptake).