TABLE 1

Effect of OA-Induced Lung Injury on ROI Analysis of Rats Injected with 111In-Labeled Agents

Injected agentROIUninjured4 h PI24 h PI
111In-PMNsLeft lung8.81 ± 2.4912.78 ± 0.19*45.54 ± 3.49
Right lung9.89 ± 2.9214.03 ± 0.7658.95 ± 5.30
Both lungs9.35 ± 2.7013.41 ± 0.4652.24 ± 4.41
Liver151.46 ± 32.65245.89 ± 21.43185.51 ± 9.35*
Heart7.41 ± 1.2712.05 ± 0.41*26.81 ± 3.14
111In-aICAM-1Left lung8.30 ± 1.1916.81 ± 0.8632.92 ± 1.27
Right lung9.32 ± 1.3819.41 ± 0.7340.95 ± 3.14
Both lungs8.81 ± 1.2718.11 ± 0.8136.92 ± 2.19
Liver44.32 ± 1.6565.81 ± 2.3892.35 ± 2.92
Heart7.68 ± 0.4113.70 ± 0.7020.19 ± 0.65
111In-nmIgGLeft lung15.22 ± 1.5938.59 ± 0.5954.78 ± 2.32
Right lung14.65 ± 1.2237.38 ± 0.8463.24 ± 2.30
Both lungs14.95 ± 1.4138.00 ± 0.7059.00 ± 2.30
Liver20.78 ± 0.8625.86 ± 0.9728.03 ± 0.84
Heart21.46 ± 0.5137.08 ± 0.9760.97 ± 0.95
  • * P < 0.05, compared with uninjured.

  • P < 0.001, compared with uninjured.

  • n = 10; all others, n = 5.

  • Values are ×10−4 mean ± SD, given as cpm/pixel/kBq.