Biodistribution of 124I-HuA33 mAb in BALB/c Nude Mice Bearing SW1222 and Control (LIM 2537) Colon Carcinoma Xenografts
| Organ | 4 h | 24 h | 48 h | 96 h | 168 h | 240 h |
|---|---|---|---|---|---|---|
| Blood | 26.60 ± 2.91 | 15.14 ± 3.70 | 9.25 ± 1.52 | 4.79 ± 1.21 | 1.50 ± 0.38 | 0.52 ± 0.20 |
| SW1222 tumor | 12.45 ± 1.39 | 31.58 ± 2.91 | 38.92 ± 5.41 | 49.99 ± 7.03 | 37.24 ± 5.38 | 17.28 ± 4.41 |
| LIM 2537 tumor | 6.27 ± 0.80 | 6.19 ± 2.93 | 4.72 ± 2.93 | 3.86 ± 0.28 | 1.07 ± 0.27 | 0.25 ± 0.04 |
| Liver | 8.07 ± 2.68 | 4.07 ± 0.93 | 0.88 ± 1.12 | 1.64 ± 0.41 | 0.29 ± 0.36 | 0.19 ± 0.21 |
| Spleen | 6.45 ± 0.68 | 4.01 ± 1.81 | 9.58 ± 7.28 | 1.00 ± 0.48 | 2.64 ± 2.92 | 0.24 ± 0.05 |
| Kidney | 9.64 ± 2.23 | 5.21 ± 1.24 | 1.76 ± 1.33 | 1.88 ± 0.35 | 1.12 ± 0.62 | 0.26 ± 0.09 |
| Skin | 3.26 ± 0.18 | 5.49 ± 0.87 | 1.24 ± 1.39 | 1.57 ± 0.67 | 0.19 ± 0.11 | 0.21 ± 0.04 |
| Bone | 2.60 ± 0.26 | 1.88 ± 0.59 | 4.37 ± 3.12 | 3.15 ± 3.77 | 1.31 ± 1.34 | 0.14 ± 0.05 |
| Lung | 11.66 ± 1.50 | 6.49 ± 1.78 | 2.73 ± 1.67 | 2.14 ± 0.79 | 1.70 ± 0.96 | 0.39 ± 0.16 |
| Heart | 7.62 ± 0.73 | 4.01 ± 1.07 | 3.58 ± 2.21 | 2.96 ± 2.58 | 0.56 ± 0.32 | 0.27 ± 0.09 |
| Stomach | 5.31 ± 1.46 | 5.03 ± 5.09 | 1.12 ± 0.71 | 1.48 ± 0.08 | 0.35 ± 0.08 | 1.06 ± 0.17 |
| Small bowel | 3.26 ± 0.82 | 2.88 ± 0.24 | 1.40 ± 0.77 | 0.44 ± 0.10 | 0.24 ± 0.10 | 0.38 ± 0.09 |
Data are mean (±SD) %ID/g tissue. n = five mice per time point.