Liposome Pharmacokinetics
| Tissue | 3 h | 4 h | 6 h | 8 h | 16 h | 24 h | 48 h | 72 h | 96 h |
|---|---|---|---|---|---|---|---|---|---|
| 2.3 (M) | 1.4 (M) | ||||||||
| Tumor | 1.8 (M) | 8 (G) | 2.0 (M) | 12 (G) | 18 (G) | 12.6 (S) | 10.6 (S) | 1.2 (M) | 2 (G) |
| 9.6 (S) | 17 (G*) | 14.2 (S) | 24 (G*) | 20 (G*) | 21 (G) | 8 (G) | 9 (S) | 4 (G*) | |
| 18 (G*) | 13 (G*) | ||||||||
| Liver | 1.2 (G) | 41.1 (M) | 17 (G) | 19 (G) | 27.5 (M) | 25.1 (M) | 23.9 (M) | 2 (G) | |
| 10.2 (S) | 14.9 (S) | 15.5 (S) | 15.1 (S) | ||||||
| 20 (G) | 16 (G) | ||||||||
| Spleen | 21 (G) | 19.6 (M) | 24 (G) | 27 (G) | 16 (M) | 10.5 (M) | 10.7 (M) | 8 (G) | |
| 15.9 (S) | 34.5 (S) | 34.2 (S) | 35.5 (S) | ||||||
| 26 (G) | 24 (G) | ||||||||
| Kidneys | 2.2 (M) | 3.74 (M) | 3.1 (M) | 2.9 (M) | |||||
| 4.7 (S) | 5.9 (S) | 4.9 (S) | 5 (S) | ||||||
| Lungs | 1.8 (M) | 2 (M) | 1.4 (M) | 1.5 (M) | |||||
| 4.5 (S) | 2.5 (S) | 1.6 (S) | 1.2 (S) | ||||||
| Red marrow | 0.5 (M) | 22.3 (G) | 0.4 (M) | 17.3 (G) | 9.3 (G) | 0.03 (M) | 0.01 (M) | 9×10−4 (M) | 0.13 (G) |
| 8.2 (S) | 5.1 (S) | 0.6 (S) | 0.04 (S) | 2×10−3 (S) | |||||
| 9 (G) | 1.8 (G) |
↵* In liver tumor.
M = MLV; S = SUV; G = GM1.
Data are percentage injected dose per gram of tissue.