Results of Three Methods to Determine Red Marrow Dose
| Method used for S(RM ← TB) determination | Equation | S(RM ← TB) (rad/μCi h) | Red marrow dose (rad/mCi) | % Dose contribution from red marrow | % Dose contribution from remainder tissues |
|---|---|---|---|---|---|
| No bone uptake | |||||
| MIRDOSE3 | 6 | 2.7 × 10−5 | 0.62 | ∼25% | ∼75% |
| MIRD 11 | 6 or 8 | 2.8 × 10−5 | 0.46 | ∼37% | ∼63% |
| MIRDOSE3 | 8 | 1.9 × 10−5 | 0.37 | ∼43% | ∼57% |
| With bone uptake* | |||||
| MIRDOSE3 | 6† | 2.7 × 10−5 | 0.41 | ∼38% | ∼62% |
| MIRD 11 | 6† or 8 | 2.8 × 10−5 | 0.17 | >99% | <1% |
| MIRDOSE3 | 8 | 1.9 × 10−5 | 0.16 | >99% | <1% |
↵* Or when bone contributions have been subtracted even though no bone uptake was present.
↵† Use of Equation 6 with correction for bone contributions to remainder of body.
Residence times used were as follows: RM = 0.2 h, RB = 30 h. For no bone uptake, the residence times in cortical and trabecular bone were set to 0.