TABLE 1.

Sample Calculation for Residence Time in Testes

Model	Time of sacrifice after injection (min)	Uptake*	Uptake (%) per organ†	Exponential fit to monkey data	Trapezoidal integration (uptake % min)	Residence time (h)‡
Sprague-Dawley rat data	5	1.463	0.062		0.155
	30	1.289	0.055		1.462
	60	1.055	0.045		1.495
	120	0.563	0.024		2.064
Rhesus monkey data	174	0.015	0.037	0.025	1.653
	194	0.006	0.015	0.021	0.519
	236	0.004	0.010	0.014	0.522
	242	0.005	0.013	0.014	0.071
	246	0.004	0.009	0.013	0.045
	268	0.007	0.017	0.011	0.287
	352	0.003	0.008	0.005	1.051	1.55 × 10⁻³
Combined						1.78 × 10⁻³

↵* Rat data, relative; monkey data, %ID/g.
↵† Rat data were scaled by factor of 0.0425. Monkey data were scaled to organ mass of 2.5 g.
↵‡ Summation of trapezoidal integration up to 352 min gives 1.55 × 10⁻³ h; analytic integration of exponential fit to monkey data after 352 min gives 2.3 × 10⁻⁴ h, for total residence time of 1.78 × 10⁻³ h.