TABLE 1

Fitted FIAU Rate Constants Generated from Tissue Time–Activity Curves in Various Tissue Regions of Patient with Recurrent Glioblastoma

RegionK1* (mL/min/g)k2* (min−1)Vb (%)
Tumor0.0071 ± 0.00180.009 ± 0.0024.2 ± 1.4
Paratumor0.00124 ± 0.000010.00157 ± 0.000012.75 ± 0.03
Scalp0.009 ± 0.0020.014 ± 0.0031.8 ± 1.0
Gray matter0.0012 ± 0.00050.0041 ± 0.00162.9 ± 0.9
White matter0.00042 ± 0.000120.0017 ± 0.00053.0 ± 0.8
  • * K1 and k2 refer to forward and reverse transport of FIAU across BBB.

  • Vb is plasma distribution volume within tissue.

  • Data are presented as mean ± SD from nonlinear least-squares fit.