TABLE 4.

Biodistribution Data for [¹²⁵I]P2 and [¹²⁵I]GP2 in Melanoma-Bearing Nude Mice and Osteosarcoma-Bearing BALB/c Mice

Organ time after injection (min)	[¹²⁵I]P2 (n = 3)		[¹²⁵I]GP2 (n = 4)
Organ time after injection (min)	Melanoma	Osteosarcoma	Melanoma	Osteosarcoma
Blood
10	0.77 ± 0.02	1.72 ± 0.44	2.20 ± 0.11	3.59 ± 0.35
60	0.17 ± 0.02	0.27 ± 0.03	0.41 ± 0.11	0.68 ± 0.25
120		0.17 ± 0.01	0.23 ± 0.08	0.60 ± 0.01
240	0.06 ± 0.02	0.12 ± 0.02	0.19 ± 0.09	0.19 ± 0.04
Serum
10	1.43 ± 0.01	3.04 ± 0.82	3.64 ± 0.18	6.36 ± 0.68
60	0.29 ± 0.03	0.43 ± 0.06	0.57 ± 0.15	1.00 ± 0.40
120		0.30 ± 0.02	0.32 ± 0.10	1.03 ± 0.07
240	0.09 ± 0.03	0.21 ± 0.04	0.24 ± 0.10	0.24 ± 0.06
Liver
10	21.96 ± 2.78	19.06 ± 0.92	2.59 ± 0.24	6.03 ± 0.53
60	11.23 ± 1.95	10.36 ± 2.27	1.22 ± 0.32	2.98 ± 0.98
120		4.22 ± 1.91	0.72 ± 0.19	2.04 ± 0.11
240	0.78 ± 0.28	2.18 ± 0.65	0.56 ± 0.18	1.23 ± 0.19
Kidneys
10	12.09*	10.94 ± 2.37	6.38 ± 0.31	14.03 ± 1.63
60	3.30 ± 0.12	2.64 ± 0.35	2.23 ± 0.43	5.01 ± 1.52
120		2.10 ± 0.23	1.62 ± 0.34	3.40 ± 0.51
240	0.28 ± 0.16	1.08 ± 0.18	1.30 ± 0.48	4.10 ± 0.67
Muscle
10	0.42 ± 0.04	0.94 ± 0.13	0.84 ± 0.05	1.75 ± 0.73
60	0.25 ± 0.05	0.43 ± 0.05	0.50 ± 0.19	0.68 ± 0.17
120		0.36 ± 0.02	0.29 ± 0.03	0.54 ± 0.11
240	0.10 ± 0.03	0.24 ± 0.04	0.23 ± 0.07	0.53 ± 0.05
Tumor
10	2.07 ± 0.32	3.50 ± 0.49	2.71 ± 0.18	5.86 ± 1.19
60	1.30 ± 0.13	2.02 ± 0.49	2.05 ± 0.55	2.58 ± 0.91
120		1.46 ± 0.16	1.81 ± 0.30	2.45 ± 0.39
240	0.41 ± 0.15	0.92 ± 0.16	1.69 ± 0.54	3.05 ± 0.31
Heart
10	0.60 ± 0.07	1.87 ± 0.35	1.31 ± 0.03	2.87 ± 0.25
60	0.22 ± 0.07	0.67 ± 0.13	0.46 ± 0.10	1.19 ± 0.34
120		0.49 ± 0.03	0.35 ± 0.08	0.91 ± 0.18
240	0.07 ± 0.02	0.24 ± 0.04	0.27 ± 0.06	0.70 ± 0.10
Brain
10	0.09 ± 0.02		0.17 ± 0.02	0.20 ± 0.01
60	0.05 ± 0.01		0.07 ± 0.01	0.09 ± 0.02
120			0.05 ± 0.01	0.09 ± 0.03
240	0.02 ± 0.01		0.05 ± 0.01	0.11 ± 0.06
Lung
10	2.36 ± 0.46	4.58 ± 1.05	3.91 ± 0.35	7.02 ± 0.91
60	0.93 ± 0.21	1.68 ± 0.18	1.51 ± 0.40	2.51 ± 0.73
120		1.06 ± 0.11	0.98 ± 0.21	1.72 ± 0.21
240	0.29 ± 0.10	0.55 ± 0.05	0.83 ± 0.20	1.49 ± 0.16
Spleen
10	1.41 ± 0.36		2.25 ± 0.11	3.97 ± 0.22
60	0.78 ± 0.26		1.23 ± 0.32	2.47 ± 0.72
120			0.99 ± 0.24	1.83 ± 0.18
240	0.10 ± 0.04		0.79 ± 0.30	1.52 ± 0.22
Intestine
10		4.31 ± 0.18	2.21 ± 0.20	4.41 ± 0.21
60		12.83 ± 1.74	2.61 ± 0.61	3.97 ± 1.32
120		15.04 ± 2.51	2.16 ± 0.41	4.33 ± 0.38
240		20.05 ± 3.40	2.92 ± 0.63	4.93 ± 1.04
Thyroid
10	2.21 ± 0.64	3.49 ± 2.27	8.80 ± 3.29	16.96 ± 4.29
60	1.95 ± 0.46	6.40 ± 2.27	7.69 ± 2.54	47.81 ± 39.42
120		15.61 ± 7.08	14.32 ± 5.21	87.59 ± 44.09
240	0.29 ± 0.08	30.02 ± 11.16	11.82 ± 6.54	174.63 ± 33.71

↵* Experiments gave only one data point.
Values are given as %ID/g ± SD.