Inhibition of Vitronectin (Vn) Binding to Immobilized αVβ3 or αVβ5 and Fibrinogen (Fb) Binding to Immobilized αIIbβ3 (n = 2)
| No. | Peptide* | IC50(αIIbβ3; Fb) (nmol/L) | IC50(αVβ5; Vn) (nmol/L) | IC50(αVβ3; Vn) (nmol/L) |
|---|---|---|---|---|
| GRGDSPK | 1,000 | >10,000 | 600 | |
| c(RGDfV) | 1,000 | 1,000 | 7 | |
| P2 | c(RGD(I)yV) | 700 | 600 | 10 |
| P4 | c(RGDf(I)Y) | 3,000 | 4,000 | 40 |
| GP1 | c(RGDyK(SAA)) | 3,000 | 4,000 | 20 |
| GP2 | c(RGD(I)yK(SAA)) | 5,000 | 2,000 | 40 |
| P5 | c(RaDYV) | NA† | NA† |