Biodistribution of Labeled Peptides in Monkeys and in Mice
| Organ | Monkey | Mouse* | ||||||
|---|---|---|---|---|---|---|---|---|
| MAG3 | MAS3 | HYNIC | DTPA | MAG3 | MAS3 | HYNIC | DTPA | |
| Kidneys | 18.4 | 27.5 | 31 | 19.4 | 15 ± 1.0 | 12 ± 2.12 | 45 ± 6.0 | 20 ± 1.0 |
| Liver | 7.8 | 2.8 | 4.6 | 5.5 | 2.3 ± 0.4 | 2 ± 0.23 | 3.2 ± 0.2 | 6.5 ± 0.3 |
| Heart | 1.3 | 0.6 | 1.7 | 1.2 | 0.03 ± 0.0 | 0.05 ± 0.01 | 0.11 ± 0.01 | 0.06 ± 0.01 |
| Spleen | 0.6 | 0.6 | 0.8 | 0.6 | 0.04 ± 0.0 | 0.05 ± 0.01 | 0.14 ± 0.02 | 0.2 ± 0.02 |
↵* Values are expressed as mean ± SD.
Values are %ID per organ at 3 h after intravenous administration for each labeled preparation in both species. For monkey studies, n = 2, except for MAG3 and MAS3 (n = 3). For mouse studies, n = 5.