TABLE 2

Biodistribution Comparison Among Analogs

Hours after injectionAnalogTumorBloodMuscleBrainHeartLungLiverSpleenPancreasKidney
0.5DOTA-ReCCMSH10.4 ± 1.751.57 ± 0.370.42 ± 0.170.07 ± 0.060.72 ± 0.211.70 ± 0.550.59 ± 0.150.59 ± 0.230.62 ± 0.3113.00 ± 3.21
DOTA-CCMSH7.26 ± 2.00*9.37 ± 0.93‡0.49 ± 0.140.26 ± 0.09†2.13 ± 0.29‡5.12 ± 1.65‡2.85 ± 0.33‡2.36 ± 0.93*0.85 ± 0.1773.40 ± 12.10‡
DOTA-CMSH8.46 ± 1.481.89 ± 0.190.29 ± 0.110.08 ± 0.020.54 ± 0.120.93 ± 0.140.69 ± 0.090.55 ± 0.110.37 ± 0.0634.10 ± 4.40‡
DOTA-NDP8.31 ± 2.020.59 ± 0.06†4.49 ± 0.47‡0.06 ± 0.030.43 ± 0.20*0.67 ± 0.20‡0.58 ± 0.060.60 ± 0.080.64 ± 0.208.96 ± 2.24*
2DOTA-ReCCMSH11.4 ± 2.890.07 ± 0.030.05 ± 0.030.04 ± 0.010.07 ± 0.050.18 ± 0.070.23 ± 0.010.09 ± 0.110.05 ± 0.038.98 ± 0.82
DOTA-CCMSH5.89 ± 1.88†1.20 ± 0.32†0.11 ± 0.04*0.06 ± 0.01*0.43 ± 0.14†1.07 ± 0.22‡1.20 ± 0.31†0.83 ± 0.26†0.21 ± 0.11*63.20 ± 15.60‡
DOTA-CMSH7.51 ± 0.98*0.41 ± 0.10†0.06 ± 0.030.03 ± 0.020.07 ± 0.070.29 ± 0.06*0.46 ± 0.04†0.32 ± 0.04†0.06 ± 0.0338.40 ± 3.60†
DOTA-NDP8.62 ± 3.300.22 ± 0.08†4.46 ± 0.72‡0.04 ± 0.020.19 ± 0.100.74 ± 0.18†0.54 ± 0.04‡0.56 ± 0.12†0.39 ± 0.09‡12.00 ± 1.96*
4DOTA-ReCCMSH9.49 ± 0.900.03 ± 0.030.09 ± 0.060.02 ± 0.020.12 ± 0.100.11 ± 0.050.20 ± 0.040.21 ± 0.100.04 ± 0.049.27 ± 2.65
DOTA-CCMSH4.32 ± 0.59‡0.82 ± 0.13‡0.17 ± 0.100.06 ± 0.030.42 ± 0.09†0.86 ± 0.34†1.37 ± 0.47†0.84 ± 0.25*0.19 ± 0.06†67.70 ± 8.10‡
DOTA-CMSH6.72 ± 1.21†0.16 ± 0.06†0.17 ± 0.100.03 ± 0.020.18 ± 0.080.30 ± 0.240.44 ± 0.04†0.32 ± 0.030.10 ± 0.0637.00 ± 4.90‡
DOTA-NDP7.45 ± 2.380.11 ± 0.03†3.32 ± 0.51‡0.01 ± 0.010.30 ± 0.260.35 ± 0.14*0.56 ± 0.11‡0.46 ± 0.16*0.52 ± 0.35*12.90 ± 2.49
24DOTA-ReCCMSH4.86 ± 1.520.01 ± 0.010.03 ± 0.010.01 ± 0.010.12 ± 0.110.06 ± 0.040.15 ± 0.020.14 ± 0.060.02 ± 0.025.64 ± 1.31
DOTA-CCMSH1.91 ± 0.56†0.08 ± 0.02†0.04 ± 0.020.03 ± 0.030.14 ± 0.040.15 ± 0.05*0.72 ± 0.03‡0.80 ± 0.27*0.08 ± 0.03*45.50 ± 5.10‡
DOTA-CMSH3.09 ± 0.32*0.02 ± 0.01†0.02 ± 0.010.02 ± 0.030.08 ± 0.080.12 ± 0.100.28 ± 0.05†0.16 ± 0.110.03 ± 0.0321.80 ± 1.70‡
DOTA-NDP2.47 ± 0.79*0.02 ± 0.020.73 ± 0.22†0.02 ± 0.020.11 ± 0.080.25 ± 0.180.38 ± 0.11*0.45 ± 0.25*0.25 ± 0.1910.20 ± 2.72*

  • ↵* 0.05 > P > 0.01.

  • ↵† 0.01 > P > 0.001.

  • ↵‡ P < 0.001.

  • Re-CCMSH = 111In-labeled DOTA-ReCCMSH.

  • Data are mean %ID/g ± SD for 5 B16/F1 murine melanoma–bearing C57 mice.