Physiologic Parameters
| Occlusion | Experiment | n | MABP (mm Hg) | HR (bpm) | RT (°C) | pH | Pco2 (mm Hg) | Po2 (mm Hg) | Glucose (mg/dL) |
|---|---|---|---|---|---|---|---|---|---|
| Before MCAO | Exp-1 vehicle | 6 | 98 ± 19 | 155 ± 20 | 36.9 ± 0.3 | 7.505 ± 0.038 | 34.4 ± 3.5 | 186.2 ± 32.1 | 66.0 ± 4.1 |
| FK506 | 5 | 98 ± 9 | 147 ± 25 | 36.5 ± 0.6 | 7.492 ± 0.011 | 35.1 ± 2.7 | 179.6 ± 14.3 | 67.5 ± 7.5 | |
| Exp-2 vehicle | 5 | 100 ± 5 | 150 ± 18 | 36.3 ± 1.0 | 7.502 ± 0.028 | 33.2 ± 2.3 | 163.8 ± 20.9 | 67.9 ± 10.1 | |
| FK506 | 5 | 103 ± 12 | 142 ± 19 | 36.9 ± 0.7 | 7.525 ± 0.027 | 31.4 ± 1.7 | 151.0 ± 13.2 | 68.0 ± 5.0 | |
| 2 h after MCAO | Exp-1 vehicle | 6 | 110 ± 10 | 171 ± 8 | 36.9 ± 0.4 | 7.492 ± 0.036 | 33.9 ± 3.8 | 189.4 ± 12.6 | 75.5 ± 8.6 |
| FK506 | 5 | 107 ± 9 | 152 ± 30 | 37.0 ± 0.8 | 7.491 ± 0.018 | 33.9 ± 1.9 | 170.0 ± 16.8 | 81.3 ± 23.1 | |
| Exp-2 vehicle | 5 | 107 ± 15 | 162 ± 18 | 37.0 ± 0.4 | 7.498 ± 0.026 | 32.8 ± 1.9 | 165.6 ± 18.3 | 79.4 ± 7.8 | |
| FK506 | 5 | 114 ± 21 | 152 ± 20 | 37.1 ± 0.3 | 7.511 ± 0.043 | 31.4 ± 2.9 | 145.4 ± 17.7 | 78.5 ± 10.0 | |
| 30 min after MCAO/R | Exp-1 vehicle | 6 | 99 ± 20 | 170 ± 9 | 37.4 ± 0.7 | 7.494 ± 0.032 | 32.3 ± 4.6 | 192.9 ± 19.9 | 80.0 ± 12.8 |
| FK506 | 5 | 100 ± 10 | 149 ± 32 | 37.0 ± 0.6 | 7.481 ± 0.029 | 35.1 ± 2.8 | 169.4 ± 19.9 | 83.0 ± 23.0 | |
| Exp-2 vehicle | 5 | 108 ± 15 | 153 ± 23 | 37.3 ± 0.2 | 7.495 ± 0.033 | 35.5 ± 2.8 | 158.1 ± 22.5 | 77.6 ± 12.3 | |
| FK506 | 5 | 116 ± 16 | 149 ± 18 | 37.3 ± 0.2 | 7.500 ± 0.042 | 33.1 ± 2.8 | 142.1 ± 16.3 | 79.8 ± 7.0 | |
| 3 h after MCAO/R | Exp-1 vehicle | 6 | 99 ± 8 | 173 ± 19 | 37.1 ± 0.5 | 7.485 ± 0.027 | 33.2 ± 3.6 | 192.7 ± 15.1 | 90.6 ± 16.6 |
| FK506 | 5 | 99 ± 14 | 164 ± 33 | 37.0 ± 0.7 | 7.486 ± 0.019 | 33.3 ± 1.0 | 173.1 ± 17.1 | 85.2 ± 18.2 | |
| Exp-2 vehicle | 5 | 101 ± 12 | 158 ± 33 | 37.2 ± 0.3 | 7.484 ± 0.027 | 33.3 ± 1.0 | 168.4 ± 19.9 | 87.8 ± 10.2 | |
| FK506 | 5 | 100 ± 13 | 144 ± 14 | 37.3 ± 0.3 | 7.484 ± 0.016 | 32.8 ± 0.9 | 142.0 ± 14.9 | 92.8 ± 9.1 |
MABP = mean arterial blood pressure; HR = heart rate; RT = rectal temperature; MCAO = MCA occlusion; Exp-1 = FK506 (0.1 mg/kg) was administered 5 min after MCA occlusion; Exp-2 = FK506 (0.1 mg/kg) was administered 175 min after MCA occlusion; MCAO/R = reperfusion of MCA occlusion.
Data are expressed as mean ± SD.