Biodistribution of 99mTc-RP128 in Healthy Volunteers at Different Times After Intravenous Injection
| Organ | Time after administration | ||||||
|---|---|---|---|---|---|---|---|
| 10 min | 30 min | 60 min | 3 h | 6 h | 8 h | 24 h | |
| Brain | 1.06 ± 0.17 | 0.84 ± 0.14 | 0.60 ± 0.09 | 0.21 ± 0.04 | 0.08 ± 0.02 | 0.05 ± 0.01 | ND |
| Liver | 4.95 ± 0.42 | 3.54 ± 0.26 | 2.60 ± 0.18 | 1.04 ± 0.14 | 0.50 ± 0.14 | 0.34 ± 0.05 | 0.04 ± 0.03 |
| Spleen | 1.27 ± 0.15 | 0.91 ± 0.07 | 0.69 ± 0.08 | 0.25 ± 0.05 | 0.11 ± 0.03 | 0.07 ± 0.01 | ND |
| Intestine | 8.65 ± 1.44 | 7.23 ± 1.17 | 5.56 ± 0.89 | 2.22 ± 0.57 | 0.94 ± 0.26 | 0.66 ± 0.16 | 0.13 ± 0.04 |
| Thyroid | 0.68 ± 0.04 | 0.55 ± 0.03 | 0.42 ± 0.03 | 0.15 ± 0.02 | 0.06 ± 0.01 | 0.04 ± 0.01 | ND |
| Kidney | 10.51 ± 2.72 | 7.01 ± 1.58 | 5.33 ± 1.18 | 2.54 ± 0.40 | 1.39 ± 0.19 | 1.11 ± 0.16 | 0.18 ± 0.03 |
| Bladder | 9.64 ± 3.32 | 19.48 ± 3.79 | 23.37 ± 8.76 | 10.48 ± 9.60 | 2.35 ± 3.04 | 2.29 ± 2.80 | 0.05 ± 0.03 |
| Gonad | 1.50 ± 0.29 | 1.48 ± 0.26 | 1.19 ± 0.22 | 0.50 ± 0.18 | 0.17 ± 0.06 | 0.12 ± 0.05 | 0.01 ± 0.01 |
| Lung | 7.37 ± 0.75 | 5.47 ± 0.49 | 3.89 ± 0.32 | 1.32 ± 0.13 | 0.49 ± 0.05 | 0.31 ± 0.03 | ND |
| Heart | 4.01 ± 0.61 | 2.88 ± 0.41 | 2.07 ± 0.35 | 0.73 ± 0.17 | 0.27 ± 0.07 | 0.17 ± 0.03 | ND |
| Knee joint | 3.97 ± 1.12 | 3.69 ± 0.97 | 3.14 ± 0.82 | 1.51 ± 0.31 | 0.61 ± 0.11 | 0.40 ± 0.07 | ND |
| Total body | 100.00 | 93.88 ± 1.21 | 82.33 ± 10.57 | 35.28 ± 11.99 | 12.53 ± 4.05 | 9.53 ± 3.51 | 1.74 ± 0.15 |
ND = not detectable.
Organ uptake is in percentage of injected dose ± SD (mean of eight subjects).