TABLE 1.

Comparative F6–679/125I-AG 8.1 Versus F6–679/188Re-AG 8.0 Biodistribution After Injection in Nude Mouse Model Grafted Subcutaneously with Human Colon Carcinoma Cell Line (LS-174-T)

%ID/gTime
5 min1 h5 h24 h48 h
125I-AG 8.1188Re-AG 8.0125I-AG 8.1188Re-AG 8.0125I-AG 8.1188Re-AG 8.0125I-AG 8.1188Re-AG 8.0125I-AG 8.1188Re-AG 8.0
Tumor4.80  ±  1.212.44  ±  0.936.88  ±  1.094.01 ± 0.4110.4 ± 1.65.42  ±  0.587.92  ±  2.784.04  ±  1.425.92  ±  0.612.12  ±  0.76
Blood6.49  ±  1.155.02  ±  0.943.58  ±  0.632.59 ± 0.533.03 ± 0.561.58  ±  0.371.32  ±  0.290.36  ±  0.210.35  ±  0.120.39  ±  0.02
Liver2.20  ±  0.508.12  ±  2.360.93  ±  0.030.97 ± 0.300.79 ± 0.090.50  ±  0.050.74  ±  0.270.25  ±  0.100.46  ±  0.040.15  ±  0.05
Kidney8.12  ±  3.204.24  ±  0.883.11  ±  0.151.29 ± 0.352.06 ± 0.170.75  ±  0.051.47  ±  0.330.29  ±  0.081.03  ±  0.170.20  ±  0.04
Intestine1.32  ±  0.373.34  ±  2.551.43  ±  0.6716.7 ± 13.40.38 ± 0.090.27  ±  0.040.17  ±  0.050.12  ±  0.030.07  ±  0.010.10  ±  0.03
Spleen1.30  ±  0.241.04  ±  0.240.62  ±  0.070.43 ± 0.090.55 ± 0.090.34  ±  0.100.48  ±  0.170.14  ±  0.020.24  ±  0.020.19  ±  0.02
Bone1.32  ±  0.311.31  ±  0.270.62  ±  0.130.54 ± 0.170.38 ± 0.050.32  ±  0.090.28  ±  0.090.23  ±  0.050.09  ±  0.020.29  ±  0.06
  • Data are expressed as mean ± SD.