Biodistribution of 99mTc-HYNIC-IL-8 and 99mTc-HYNIC-Lysozyme in Rabbits with E. coli Infections at Eight Hours After Injection
| Organ | %ID/g | |
|---|---|---|
| 99mTc-HYNIC-IL-8 (n = 6) | 99mTc-HYNIC-lysozyme (n = 5) | |
| Blood | 0.028 ± 0.001 | 0.105 ± 0.006 |
| Abscess | 0.33 ± 0.06 | 0.025 ± 0.003 |
| Muscle | 0.0026 ± 0.0001 | 0.0041 ± 0.0008 |
| Lung | 0.19 ± 0.04 | 0.077 ± 0.011 |
| Spleen | 0.64 ± 0.06 | 0.119 ± 0.005 |
| Kidney | 1.47 ± 0.06 | 1.77 ± 0.06 |
| Liver | 0.14 ± 0.01 | 0.124 ± 0.006 |
| Intestine | 0.025 ± 0.002 | 0.028 ± 0.001 |
| Ratio | ||
| Abscess-to- muscle | 127 ± 23 | 6.7 ± 1.1 |
| Abscess-to- blood | 11.9 ± 2.2 | 0.24 ± 0.03 |
| Total uptake | ||
| Infected tissue (%ID) | 4.9 ± 0.7 | 0.44 ± 0.05 |
| Kidneys (%ID) | 28 ± 1 | 35 ± 1 |
Values are expressed as mean ± SEM.