Kinetic Modeling Parameters Derived from Graphic Analysis of [123I]ADAM Uptake in Brain Combined with Metabolite-Corrected Arterial Plasma Data
| Parameter | MB t* (min) | DV (mL/mL) | |||
|---|---|---|---|---|---|
| CER | MB | THAL | STR | ||
| Mean ± SD | 138 ± 28 | 2.25 ± 0.48 | 4.86 ± 1.06 | 3.83 ± 0.91 | 3.53 ± 0.68 |
| Test–retest (%) | 13.1 | 14.5 | 15.5 | 14.7 | |
| Intersubject (%) | 10.4 | 11.5 | 13.9 | 9.6 | |
| ri | 0.14 | 0.40 | 0.0 | 0.51 | |
MB = midbrain; t
↵* = time after which graphic analysis curve becomes linear; CER = cerebellum; THAL = thalamus; STR = striatum; Test–retest = mean absolute difference between each subject’s mean value and each individual value; Intersubject = between-subject variability, calculated same way as Test–retest; ri = intraclass correlation coefficient.