Diagnostic Performance of 99mTc-Sestamibi Breast Imaging as Function of Patients' Age
| Parameter | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| ≤50 y old | >50 y old | ≤50 y old | >50 y old | ≤50 y old | >50 y old | ≤50 y old | >50 y old | ≤50 y old | >50 y old | |
| Overall | 75.3 | 75.5 | 78.7 | 88.3 | 58.1 | 87.3 | 89.1 | 77.1 | 77.8 | 81.7 |
| (61/81) | (117/155) | (163/207) | (128/145) | (61/105) | (117/134) | (163/183) | (128/166) | (224/288) | (245/300) | |
| Palpable abnormalities | ||||||||||
| Institutional | 84.9 | 87.5 | 75.7 | 76.9 | 64.3 | 88.6 | 90.7 | 75.0 | 78.8 | 84.0 |
| (45/53) | (70/80) | (78/103) | (30/39) | (45/70) | (70/79) | (78/86) | (30/40) | (103/156) | (100/119) | |
| Reader 1 | 70.8 | 79.2 | 77.5 | 88.2 | 63.0 | 93.4 | 83.1 | 66.7 | 75.2 | 82.1 |
| (34/48) | (57/72) | (69/89) | (30/34) | (34/54) | (57/61) | (69/83) | (30/45) | (103/137) | (87/106) | |
| Reader 2 | 72.3 | 78.7 | 81.9 | 91.4 | 69.4 | 95.2 | 84.0 | 66.7 | 78.5 | 82.7 |
| (34/47) | (59/75) | (68/83) | (32/35) | (34/49) | (59/62) | (68/81) | (32/48) | (102/130) | (91/110) | |
| Reader 3 | 71.4 | 77.9 | 83.8 | 89.5 | 68.6 | 93.8 | 85.6 | 66.7 | 79.7 | 81.7 |
| (35/49) | (60/77) | (83/99) | (34/38) | (35/51) | (60/64) | (83/97) | (34/51) | (118/148) | (94/115) | |
| Nonpalpable abnormalities | ||||||||||
| Institutional | 57.1 | 62.7 | 81.7 | 92.5 | 45.7 | 85.5 | 87.6 | 77.8 | 76.5 | 80.1 |
| (16/28) | (47/75) | (85/104) | (98/106) | (16/35) | (47/55) | (85/97) | (98/126) | (101/132) | (145/181) | |
| Reader 4 | 50.0 | 52.8 | 88.8 | 98.1 | 53.8 | 95.0 | 87.2 | 75.7 | 80.7 | 80.0 |
| (14/28) | (38/72) | (95/107) | (106/108) | (14/26) | (38/40) | (95/109) | (106/140) | (109/135) | (144/180) | |
| Reader 5 | 33.3 | 45.5 | 94.2 | 99.1 | 57.1 | 96.8 | 85.8 | 74.6 | 82.7 | 78.6 |
| (8/24) | (30/76) | (97/103) | (106/107) | (8/14) | (30/31) | (97/113) | (106/142) | (105/127) | (136/173) | |
| Reader 6 | 44.8 | 56.6 | 87.4 | 93.9 | 50.0 | 86.0 | 84.9 | 76.4 | 78.0 | 78.9 |
| (13/29) | (43/76) | (90/103) | (107/114) | (13/26) | (43/50) | (90/106) | (107/140) | (103/132) | (150/190) | |
PPV = positive predictive value; NPV = negative predictive value.