Location and Peaks of Significant (P < 0.001) Decreases in Adjusted rCBF
| z score | Coordinate | Structure | ||
|---|---|---|---|---|
| x | y | z | ||
| 4.94 | 56 | −54 | 12 | Right middle temporal gyrus |
| 4.68 | 6 | 44 | 10 | Right anterior cingulate gyrus |
| 4.52 | 62 | −54 | 22 | Right inferior parietal lobules |
| 4.20 | 48 | −56 | 24 | Right inferior parietal lobules |
| 3.97 | 42 | 12 | −4 | Right inferior frontal gyrus |
| 3.91 | 40 | −18 | 10 | Right insula |
| 3.89 | 58 | −8 | 8 | Right superior temporal gyrus |
| 3.86 | −10 | 30 | 26 | Left anterior cingulate gyrus |
| 3.70 | 4 | 42 | 18 | Right middle frontal gyrus |
| 3.62 | 48 | 44 | 18 | Right middle frontal gyrus |
| 3.54 | 44 | 28 | 10 | Right inferior frontal gyrus |
Data are for placebo-treated AD patients compared with donepezil-treated AD patients from baseline study to follow-up study.