TABLE 2

Neuropsychological Test Results

Test	Donepezil-treated patients		Placebo-treated patients
Test	Baseline	Follow-up	Baseline	Follow-up
MMSE	22.1 ± 3.3	19.9 ± 4.4	22.2 ± 3.4*	18.7 ± 3.7*
RCPM	24.7 ± 5.9	23.7 ± 6.6	23.0 ± 8.5	20.9 ± 10.4
Digit span
Forward digits	5.2 ± 0.9	5.3 ± 0.7^†	4.9 ± 1.1*	4.1 ± 1.1*^†
Reverse digits	3.7 ± 1.0	3.9 ± 1.0^†	3.8 ± 0.9	2.9 ± 1.7^†
Word learning (10 words)
30-min delayed recall	0.4 ± 0.7	0.3 ± 0.4	0.5 ± 1.3	0.2 ± 0.5
Story recall (15 elements)
Immediate	3.8 ± 2.1	3.9 ± 2.2	3.4 ± 2.4	2.5 ± 2.7
30-min delayed recall	0.1 ± 0.3	0.2 ± 0.6	0.4 ± 0.9	0.3 ± 1.1
Ray-Osterrieth complex figure
Copy	33.6 ± 2.5	26.2 ± 13.0	29.5 ± 8.9	25.4 ± 12.5
Immediate recall	7.4 ± 4.7	5.4 ± 3.9	4.4 ± 3.8	3.4 ± 3.0
30-min delayed recall	3.8 ± 4.2	2.3 ± 2.5^†	1.7 ± 3.1	0.6 ± 1.5^†
Stroop
Dot	48.1 ± 6.9	28.1 ± 9.1^†	47.3 ± 25.6	41.3 ± 20.8^†
Word	49.5 ± 19.4	67.5 ± 27.9	75.9 ± 35.9	81.8 ± 35.2
Word-dot	33.5 ± 23.7	39.3 ± 26.0	28.6 ± 18.4*	48.3 ± 31.3*

↵*Mean differs from baseline, P < 0.05.
↵^†Mean differs from placebo-treated patients, P < 0.05.
MMSE = Mini-Mental State Examination; RCPM = Raven’s Coloured Progressive Matrices.
Values are mean ± SD.