TABLE 1.

Conceptual Difference Between Anatomic Standardization and Registration

ParameterAnatomic standardization*Registration†
MaterialsImages of different subjectsImages of same subject
Same modality or tracerSame or different modality or tracer
TransformationNonlinear in generalRigid body
Standard brainTo be usedNot to be used
AtlasApplicable and availableNot essential, only used as a reference
SolutionNo single true solutionSingle true solution exists
Study subjectPopulationIndividual
AnalysisStatistical analysisMultilateral examination

  • ↵* Also called spatial normalization.

  • ↵† In the narrow sense.