TABLE 3.

Cerebral Glucose Metabolism in Aged Monkeys and Aged Humans

Monkey (A)Human (H)A − H (%)
Cortical structures
 Lateral parietal1.07 ± 0.021.01 ± 0.035*
 Lateral temporal0.99 ± 0.030.97 ± 0.023
 Lateral frontal1.00 ± 0.031.12 ± 0.03−12
 Lateral occipital1.00 ± 0.071.01 ± 0.04−1
 Cuneus/lingual gyrus1.17 ± 0.071.24 ± 0.07−6
 Pre-/postcentral gyrus1.00 ± 0.030.99 ± 0.041
 Principle sulcus1.10 ± 0.041.14 ± 0.04−3
 Supramarginal gyrus1.14 ± 0.041.00 ± 0.0312
 Anterior cingulate1.10 ± 0.051.08 ± 0.032
 Posterior cingulate1.12 ± 0.021.23 ± 0.04−10
Subcortical structures
 Thalamus1.19 ± 0.081.11 ± 0.077
 Caudate1.04 ± 0.061.08 ± 0.03−3
Others
 Cerebellum0.92 ± 0.030.99 ± 0.07−7
 Vermis1.25 ± 0.050.92 ± 0.0627
  • * P < 0.005.

  • P < 0.0005.

  • P < 0.00005.

  • Regional glucose metabolism normalized to global activity (mean ± SD). A − H = (A − H)/A × 100 represents percentage difference between aged monkeys and aged humans. Positive values denote higher metabolism in monkeys.