TABLE 3.

Palmitate Oxidation and FOP Kinetic Parameter Estimates in Isolated Rat Liver

ParameterNormoxic condition (95% O2) (n = 5)Hypoxic condition (15% O2) (n = 5)Percentage change
k1 (mL/min/g dry weight)2.81 ± 0.493.09 ± 0.90
k2 (per minute)0.135 ± 0.0460.354 ± 0.054+162*
k3 (per minute)0.087 ± 0.0450.081 ± 0.018
k4 (per minute)0.036 ± 0.0100.041 ± 0.006
DV1 (mL/g dry weight)22.9 ± 8.69.0 ± 3.3−61†
k3/k42.30 ± 0.912.04 ± 0.54
DV2 (mL/g dry weight)47.2 ± 10.518.1 ± 7.6−62‡
DVtot (mL/g dry weight)70.1 ± 13.927.2 ± 10.3−61‡
Fractional palmitate oxidation rate (mL/min/g dry weight)1.31 ± 0.300.587 ± 0.080*−55†

  • ↵* P < 0.0001, vs. normoxic.

  • ↵† P < 0.01, vs. normoxic.

  • ↵‡ P < 0.0005, vs. normoxic.