TABLE 1.

Uptake of [¹⁸F]FOP in Fasting Rats

Tissue	Control			Etomoxir 15 min (n = 5)
Tissue	15 min (n = 5)	30 min (n = 5)	60 min (n = 3)	Etomoxir 15 min (n = 5)
Heart	0.023 ± 0.003	0.046 ± 0.003*	0.029 ± 0.005	0.080 ± 0.028*
Blood	0.059 ± 0.007	0.088 ± 0.006†	0.072 ± 0.004*	0.146 ± 0.041†
Lung	0.044 ± 0.008	0.055 ± 0.007	0.041 ± 0.001	0.101 ± 0.037†
Liver	1.531 ± 0.252	1.760 ± 0.110	0.979 ± 0.078†	1.280 ± 0.338
Kidney	0.101 ± 0.031	0.127 ± 0.103	0.066 ± 0.016	0.108 ± 0.029
Bone	0.102 ± 0.032	0.170 ± 0.024†	0.276 ± 0.080†	0.049 ± 0.008*
Brain	0.011 ± 0.031	0.014 ± 0.002	0.013 ± 0.001	0.026 ± 0.010*
Skeletal muscle	0.013 ± 0.003	0.015 ± 0.002	0.017 ± 0.001	0.030 ± 0.007†

↵* P < 0.05 vs. 15-min controls.
↵† P < 0.01 vs. 15-min controls.
Data are % dose kg/g. Control rats were Sprague-Dawley female rats that weighed 180–200 g and had fasted overnight. Etomoxir-treated rats were given 40 mg/kg etomoxir 2 h before tracer injection. Uptake is normalized to body mass (kg).