TABLE 1.

Effect of Eniluracil (EU) on Biodistribution of Radiolabel in Tumor-Bearing Rats 2 Hours After Intravenous Injection of [18F]FU or [3H]FU

Organ or tissueSUV*
FU-only[18F]FU + EU
[18F]FU[3H]FU
Tumor0.67 ± 0.08 (4)†0.81 ± 0.03 (2)1.57 ± 0.20 (12)
Plasma0.64 ± 0.08 (2)0.79 (1)0.54 ± 0.03 (6)
Skeletal muscle0.28 ± 0.03 (2)†0.63 (1)0.58 ± 0.05 (5)
Cortical bone1.13 ± 0.09 (2)‡0.54 ± 0.08 (5)
Lung0.62 ± 0.08 (2)0.99 (1)0.75 ± 0.05 (5)
Liver3.47 ± 0.50 (2)†2.09 (1)1.55 ± 0.13 (5)
Spleen0.54 ± 0.08 (2)†1.24 ± 0.09 (5)
Kidney7.02 ± 2.24 (2)†1.99 (1)2.44 ± 0.07 (5)
Small intestine0.71 ± 0.08 (2)0.75 (1)1.25 ± 0.22 (5)

  • ↵* SUV = (activity/g tissue) ÷ (activity injected/g body weight).

  • ↵† Significantly different (P < 0.01) from FU + EU.

  • ↵‡ Significantly different (P < 0.05) from FU + EU.

  • Data are presented as mean ± SEM (no. of observations).