Summary of Techniques and Drainage Patterns in SLND Series Using Breast Lymphoscintigraphy
| Study | n | Agent | Total MBq | Total injection volume* (mL) | Early/late scan timing after injection (h) | Views | Overall sentinel node detection (%) | AX drainage† (%) | IM drainage† (%) | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | Exclusive | Total | Exclusive | ||||||||
| Uren et al. (12) | 34 | ASC | 50–70 | 0.2–0.4 | 0/2.5 | A, L, O | 91 | 94 | 58 | 39 | 6 |
| Roumen et al. (10) | 83 | CA | 60 | 2 | 4/18 | A, L | 80 | 97 | 86 | 11 | 3 |
| De Cicco et al. (9) | 250 | CA or ASC | 7 | 0.4 or 0.5‡ | 0.25–0.5/3 | A, AO | 98 | 98 | 98 | 2 | 2 |
| Borgstein et al. (7) | 130 | CA | 40 | 4 | 2/18 | A, L | 91 | 98 | 81 | 18 | 2 |
| O'Hea et al. (8) | 56 | SC | 11 | 4 | 0.8–1§ | A, L | 75 | 100 | 86 | 14 | 0 |
| van der Ent et al. (11) | 70 | NC | 370 | 4 | 16§ | A, AL | NR | 97 | NR | 34 | NR |
| Current series | 76 | SC | 12–16 | 3–8 | 0/¶ | A, MOVA | 100 | 99 | 79 | 20 | 1 |
↵* All injections were peritumoral except for series from De Cicco (9).
↵† Values represent drainage patterns after scan failures were excluded.
↵‡ 0.4 mL for subdermal injection (175 patients) and 0.5 mL for peritumoral injection (75 patients).
↵§ Only 1 scan obtained at these times.
↵¶ Images obtained continuously until sentinel node visualized, unless no uptake after 4 h.
A = anterior; L = lateral; O = oblique; CA = colloidal albumin; AO = antero-oblique; SC = sulfur colloid; NC = nanocolloid; AL = anterolateral; NR = not recorded.