Gastric SRS Localization Findings in ZES Patients
| Characteristic | Gastric SRS localization finding | |||
|---|---|---|---|---|
| Positive (n = 19) | Negative (n = 143) | |||
| Diffuse pattern* | Diffuse and focal pattern† | Total positive | ||
| Total no. of patients (n = 162) | 15 (79) | 4 (21) | 19 (100) | 143 (100) |
| MEN-1 present (n = 39) | 12 (63) | 4 (21) | 16 (84)‡ | 23 (16) |
| MEN-1 absent (n = 123) | 3 (16) | 0 (0) | 3 (16) | 120 (84) |
| Gastric carcinoid present (n = 16) | 8 (42) | 4 (21) | 12 (63)‡ | 4 (2) |
| MEN-1 present (n = 14) | 8 (42) | 4 (21) | 12 (63) | 2 (1) |
| MEN-1 absent (n = 2) | 0 (0) | 0 (0) | 0 (0) | 2 (1) |
| Gastric carcinoid absent (n = 146) | 7 (37) | 0 (0) | 7 (37)‡ | 139 (97) |
| MEN-1 present (n = 25) | 4 (21) | 0 (0) | 4 (21) | 21 (15) |
| MEN-1 absent (n = 121) | 3 (16) | 0 (0) | 4 (21) | 118 (82) |
| Gastric nodule present with gastric carcinoid (n = 10)§ | 5 (26) | 3 (16) | 8 (42) | 2 (1) |
| MEN-1 present (n = 9) | 5 (26) | 3 (16) | 8 (42) | 1 (0.5) |
| MEN-1 absent (n = 1) | 0 (0) | 0 (0) | 0 (0) | 1 (0.5) |
| Gastric nodule absent with gastric carcinoid (n = 6)§ | 3 (15) | 1 (5) | 4 (21) | 2 (1) |
| MEN-1 present (n = 5) | 3 (15) | 1 (5) | 4 (21) | 1 (0.5) |
| MEN-1 absent (n = 1) | 0 (0) | 0 (0) | 0 (0) | 1 (0.5) |
↵* Gastric SRS localization was initially reported for 6 of 15 patients with diffuse pattern and detected only on detailed review in 9 patients. Each initially unreported patient had MEN, with 8 patients having gastric carcinoid and 2 patients not having gastric carcinoid.
↵† Gastric SRS localization was initially unreported for 1 of 4 patients who had MEN with diffuse and focal pattern and detected only on detailed review. This patient had MEN-1 with advanced gastrinoma and invasive carcinoid tumors necessitating total gastrectomy.
↵‡ P < 0.00001 compared with patients with negative SRS (n = 146).
↵§ Gastric nodule present or absent refers to endoscopic findings in stomach at time diagnosis of gastric carcinoid tumor was made histologically.
Values in parentheses are percentages of patients with either positive or negative SRS localization with indicated SRS pattern and characteristic.