Study | Islet | Pancreas | Brain |
In vitro | |||
Endocrine vs. exocrine | 10.6 ± 1.9 vs. 2.8 ± 1.2; ratio, 3.8* | NA | NA |
Control vs. haloperidol | 6.4 ± 0.4 vs. 2.1 ± 0.1; ratio, 3.1* | 10.6 ± 0.2 vs. 4.4 ± 0.5; ratio, 2.4† | 330.1 ± 12.7 vs. 4.3 ± 0.2; ratio, 77† |
Control vs. streptozotocin | NA | 6.2 ± 0.2 vs. 2.7 ± 0.1; ratio, 2.3‡ | 38.7 ± 4.9 vs. 44.1 ± 10.1; ratio, 0.9‡ |
Ex vivo | |||
Control vs. haloperidol | NA | 12.7 ± 2.3 vs. 5.6 ± 0.9; ratio, 2.3§ | Ratio, 22∥ |
Control vs. streptozotocin | NA | 5.9 ± 0.8 vs. 1.8 ± 0.1; ratio, 3.3§ | NA |
↵* Autoradiography in isolated rat islet cells.
↵† Autoradiography on tissue slices in absence and presence of haloperidol.
↵‡ Autoradiography on tissue slices in control and streptozotocin-treated animals.
↵§ Small-animal PET on whole isolated pancreas.
↵∥ Small-animal PET on whole isolated brains.
NA = not applicable or not available.
Data are mean ± SD unless otherwise indicated.