TABLE 2

Biodistribution Results of ⁶⁴Cu-CB-TE2A-LM3 and ⁶⁴Cu-NODAGA-LM3 in Nude Mice Bearing HEK-sst2 Tumor Xenografts

Organ	1 h	4 h	4 h blocking^*	24 h
⁶⁴Cu-CB-TE2A-LM3
Blood	0.79 ± 0.32	0.19 ± 0.09	0.12 ± 0.01	0.17 ± 0.08
Heart	0.75 ± 0.15	0.25 ± 0.03	0.12 ± 0.03	0.21 ± 0.07
Liver	5.66 ± 0.67	4.44 ± 1.89	4.35 ± 0.27	3.25 ± 0.70
Spleen	3.16 ± 0.89	1.30 ± 0.27	0.79 ± 0.28	1.04 ± 0.26
Lung	8.27 ± 1.17	4.45 ± 1.17	0.90 ± 0.19	2.46 ± 0.81
Kidney	19.78 ± 3.99	19.57 ± 3.85^†	16.40 ± 0.86	11.05 ± 2.81^†
Stomach	27.92 ± 3.04	21.79 ± 4.13	0.50 ± 0.12	5.61 ± 1.66
Intestine	3.41 ± 0.59	1.21 ± 0.40	0.33 ± 0.04	0.55 ± 0.13
Adrenal	6.16 ± 1.59	2.38 ± 0.88	0.01 ± 0.01	3.92 ± 1.02
Pancreas	43.89 ± 13.54	20.99 ± 4.80	0.25 ± 0.03	3.37 ± 1.55
Muscle	0.48 ± 0.25	0.23 ± 0.07	0.05 ± 0.01	0.30 ± 0.13
Bone	2.89 ± 1.30	1.57 ± 0.41	0.32 ± 0.11	1.50 ± 0.36
Tumor	19.26 ± 3.75^‡	26.87 ± 3.28^‡	3.83 ± 1.06	21.55 ± 2.14^†
⁶⁴Cu-NODAGA-LM3
Blood	0.84 ± 0.10	0.11 ± 0.05	0.10 ± 0.02	0.12 ± 0.05
Heart	0.54 ± 0.08	0.14 ± 0.07	0.20 ± 0.01	0.19 ± 0.08
Liver	2.23 ± 0.48	0.96 ± 0.14	0.90 ± 0.20	0.78 ± 0.15
Spleen	0.94 ± 0.21	0.21 ± 0.10	0.21 ± 0.06	0.19 ± 0.10
Lung	5.89 ± 1.51	0.60 ± 0.17	0.67 ± 0.25	0.54 ± 0.13
Kidney	10.90 ± 1.10	4.41 ± 0.74^†	3.52 ± 0.93	1.25 ± 0.47^†
Stomach	9.17 ± 2.49	1.31 ± 0.55	0.43 ± 0.14	0.46 ± 0.17
Intestine	1.35 ± 0.12	0.46 ± 0.04	0.46 ± 0.01	0.33 ± 0.06
Adrenal	0.73 ± 0.15	0.02 ± 0.01	0.22 ± 0.05	0.02 ± 0.01
Pancreas	16.26 ± 4.04	0.55 ± 0.10	0.12 ± 0.03	0.23 ± 0.09
Muscle	0.20 ± 0.03	0.03 ± 0.01	0.02 ± 0.01	0.02 ± 0.01
Bone	2.23 ± 1.01	0.39 ± 0.07	0.01 ± 0.01	0.30 ± 0.16
Tumor	35.46 ± 5.70^‡	37.88 ± 3.43^‡	0.52 ± 0.18	14.79 ± 2.40^†

↵* Coinjection with 2,000-fold excess of DOTA-LM3.
↵† P < 0.01, statistically significant between ⁶⁴Cu-CB-TE2A-LM3 and ⁶⁴Cu-NODAGA-LM3.
↵‡ P < 0.05, statistically significant between ⁶⁴Cu-CB-TE2A-LM3 and ⁶⁴Cu-NODAGA-LM3.
Results are %ID/g ± SD (n = 3–7).