TABLE 1

Blood-to-Cell Clearance of 18F-FDG and 11C-MG as Measure of Hepatic Blood Perfusion in Pigs

18F-FDG (n = 6)11C-MG (n = 6)
ParameterCorrelation between Embedded Image and Q, rRelative deviation of Embedded Image from QCorrelation between Embedded Image and Q, rRelative deviation of Embedded Image from Q
Measured Embedded Image, 60-min; 2-tissue compartmental model for 18F-FDG, 1-tissue compartmental model for 11C-MG0.60 (P = 0.14)0.08 ± 0.09 (P = 0.43)0.26 (P = 0.61)0.11 ± 0.10 (P = 0.28)
Measured Embedded Image, 3-min; 1-tissue compartmental model for both 18F-FDG and 11C-MG0.88 (P = 0.02)0.10 ± 0.04 (P = 0.08)0.58 (P = 0.23)0.32 ± 0.08 (P = 0.01)
Model-derived Embedded Image, 3-min; 1-tissue compartmental model for both 18F-FDG and 11C-MG0.94 (P = 0.01)0.19 ± 0.11 (P = 0.13)0.77 (P = 0.07)0.27 ± 0.12 (P = 0.07)

  • Embedded Image = PET-estimated blood-to-cell clearance of tracer (mL of blood/mL of liver tissue/min); Q = blood perfusion of liver tissue measured by ultrasound transit-time flow meters (mL of blood/mL of liver tissue/min); Embedded Image = measured dual-input time–activity curve (kBq/mL of blood); Embedded Image = estimated dual-input time–activity curve (kBq/mL of blood); r = Pearson correlation coefficient for correlation between individual pairs of Embedded Image and Q. P < 0.05 was considered to indicate statistically significant correlation. Relative deviation of Embedded Image from Q is presented as mean ± SEM (mean deviations with P < 0.05 were considered statistically significantly different from zero; 1-sample t test).