Biodistribution of 11C-GW405833 in Wistar Rats
| Percentage injected dose ± SD | Standardized uptake value ± SD | |||||
| Organ | 2 min | 30 min | 60 min | 2 min | 30 min | 60 min |
| Kidneys | 6.1 ± 0.4 | 2.2 ± 1.2 | 3.1 ± 1.1 | 7.6 ± 1.2 | 2.6 ± 1.6 | 3.4 ± 1.3 |
| Urine | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.2 ± 0.1 | — | — | - |
| Liver | 32.3 ± 3.3 | 63.9 ± 1.2 | 61.8 ± 4.4 | 10.9 ± 1.1 | 15.2 ± 0.4 | 14.9 ± 1.6 |
| Spleen | 1.6 ± 0.2 | 0.3 ± 0.0 | 0.1 ± 0.0 | 6.7 ± 1.5 | 1.1 ± 0.1 | 0.6 ± 0.0 |
| Pancreas | 1.2 ± 0.1 | 0.3 ± 0.0 | 0.2 ± 0.1 | 4.7 ± 0.7 | 0.9 ± 0.1 | 0.8 ± 0.2 |
| Lungs | 10.5 ± 5.0 | 0.8 ± 0.3 | 0.6 ± 0.0 | 17.8 ± 7.1 | 1.3 ± 0.3 | 1.1 ± 0.1 |
| Heart | 1.9 ± 0.1 | 0.1 ± 0.0 | 0.1 ± 0.0 | 6.3 ± 0.9 | 0.4 ± 0.0 | 0.4 ± 0.0 |
| Intestines | 10.3 ± 0.6 | 4.3 ± 0.2 | 5.7 ± 0.9 | — | — | - |
| Stomach | 2.1 ± 0.6 | 2.9 ± 0.1 | 4.7 ± 2.6 | — | — | - |
| Blood | 4.5 ± 0.9 | 0.9 ± 0.1 | 1.1 ± 0.2 | 0.6 ± 0.1 | 0.1 ± 0.0 | 0.2 ± 0.0 |
| Brain | 1.4 ± 0.2 | 0.3 ± 0.0 | 0.2 ± 0.0 | 1.8 ± 0.3 | 0.4 ± 0.0 | 0.2 ± 0.0 |
Percentage injected dose was calculated as cpm in organ divided by total cpm recovered. Standardized uptake values were calculated as (radioactivity in cpm in organ/weight of organ in grams)/(total counts recovered/body weight in grams). Data are expressed as mean ± SD for 3 independent experiments.