TABLE 1.

Dosimetry of 225Ac-PRIT in BT-474 Model

Parameter[225Ac]Ac-Pr, 0.60 nmol[225Ac]Ac-Pr, 26.9 nmolRatio
Tumor5.670 Gy/kBq0.170 Gy/kBq33.4:1
Kidney0.095 Gy/kBq0.070 Gy/kBq1.4:1
Kidney TI60.02.5

  • Dosimetry for 225Ac-PRIT (296 kBq, 26.9 nmol) was extrapolated from 225Ac-PRIT (37 kBq, 0.60 nmol) data (Fig. 3C; Supplemental Table 3).