Definition of RECIP 1.0
| Definition | Criterion |
|---|---|
| New lesion | |
| Any new focal uptake of PSMA ligand | |
| Higher than surrounding background | |
| With tumor SUVmax > blood-pool SUVmax | |
| Not present on baseline scan (tumor SUVmax < blood-pool SUVmax) | |
| With tumor uptake not attributable to physiologic uptake or pitfalls | |
| Any new malignant lesion detected on follow-up CT images independent of PSMA ligand uptake | |
| RECIP 1.0 classification | |
| RECIP CR | Absence of any PSMA ligand uptake on follow-up PET scan |
| RECIP PR | ≥30% decrease in TTV without appearance of new lesion(s) |
| RECIP PD | ≥20% increase in TTV with appearance of new lesion(s) |
| RECIP SD | Does not meet the criteria for CR, PR, or PD |