TABLE 2

Diagnostic Performance of Quantitative Parameters of ¹⁸F-FET Uptake in Visual Analysis

Parameter	AUC	Sensitivity	Specificity	Accuracy	PPV	NPV	Cutoff	P^*
All patients (n = 439)
TBR_mean	0.76	0.69	0.70	0.69	0.90	0.37	1.95	<0.001
TBR_max-2mL	0.78	0.73	0.67	0.72	0.89	0.40	1.95	<0.001
TBR_max	0.78	0.69	0.78	0.71	0.92	0.40	3.05	<0.001
TTP	0.63	0.67	0.58	0.65	0.86	0.32	36 min	<0.001
Slope	0.65	0.58	0.67	0.60	0.87	0.30	0.2 SUV/h	<0.001
Intercept	0.76	0.71	0.67	0.70	0.89	0.38	2.00	<0.001
Patients with clearly positive or clearly negative findings (n = 301)
TBR_mean	0.84	0.82	0.78	0.81	0.94	0.52	1.95	<0.001
TBR_max-2mL	0.86	0.85	0.81	0.84	0.95	0.57	1.95	<0.001
TBR_max	0.86	0.88	0.76	0.85	0.94	0.60	2.85	<0.001
TTP	0.66	0.67	0.59	0.66	0.87	0.31	36 min	<0.001
Slope	0.65	0.61	0.68	0.62	0.88	0.30	0.2 SUV/h	<0.001
Intercept	0.84	0.89	0.71	0.86	0.93	0.63	1.76	<0.001
Patients with borderline readings (n = 138)
TBR_mean	0.46	0.38	0.55	0.42	0.73	0.22	1.95	ns
TBR_max-2mL	0.45	0.59	0.33	0.53	0.74	0.20	1.85	ns
TBR_max	0.59	0.43	0.67	0.49	0.80	0.27	2.95	ns
TTP	0.58	0.68	0.55	0.64	0.83	0.35	36 min	ns
Slope	0.66	0.86	0.48	0.77	0.84	0.52	0.65 SUV/h	0.005
Intercept	0.51	0.47	0.55	0.49	0.77	0.24	2.00	ns

↵* P value according to ROC analysis.
AUC = area under the ROC curve; NPV = negative predictive value; PPV = positive predictive value; TBR_max = maximum SUV in tumor divided by mean SUV of background region; TBR_max-2mL = mean SUV of 2 mL ROI centered on tumor maximum divided by mean SUV of background region; TBR_mean = mean SUV of tumor area (>1.6) divided by mean SUV of background region; TTP = time-to-peak; ns = not significant.