Adverse Events in at Least 3 Patients
| Adverse event | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|---|---|---|---|
| Anemia | 11 (61) | 5 (28) | ||
| Thrombocytopenia | 6 (33) | 3 (17) | 5 (28) | |
| Leucopenia | 4 (22) | 6 (33) | 3 (17) | |
| Lymphocytopenia | 1 (6) | 5 (28) | 10 (56) | 1 (6) |
| Neutropenia | 1 (6) | 5 (28) | 3 (17) | |
| Nausea | 11 (61) | 3 (17) | ||
| Fatigue | 9 (50) | 4 (22) | 1 (6) | |
| AST increased | 8 (44) | |||
| Hyponatremia | 5 (28) | 1 (6) | ||
| Hypochloremia | 5 (28) | |||
| Diarrhea | 5 (28) | |||
| Hypokalemia | 5 (28) | |||
| ALT increased | 4 (22) | 2 (11) | ||
| ALP increased | 4 (22) | 1 (6) | ||
| Weight loss | 4 (22) | 1 (6) | ||
| Bicarbonate increased | 4 (22) | |||
| Alopecia | 4 (22) | |||
| Abdominal pain | 3 (17) | 1 (6) | 1 (6) | |
| Creatinine increased | 3 (17) | 1 (6) | ||
| Dizziness | 3 (17) | 1 (6) | ||
| Dyspnea | 3 (17) | |||
| Bilirubin increased | 2 (11) | 1 (6) | 1 (6) | |
| Hypotension | 2 (11) | 2 (11) | ||
| Constipation | 2 (11) | 1 (6) | ||
| Pain | 1 (6) | 2 (11) | 1 (6) |
AST = aspartate transaminase; ALT = alanine transaminase; ALP = alkaline phosphatase.
Data are number followed by percentage in parentheses.