FDA-Approved Diagnostic Agents
| Agent | Amount | Image display | Number of regions for a positive scan |
|---|---|---|---|
| Amyloid | |||
| Florbetapir F-18 | 370 MBq (10 mCi) | Color scale: gray scale or inverse gray scale | 2, or only 1 if gray matter uptake exceeds white matter uptake |
| Regions: temporal, parietal (including precuneus), frontal, and occipital | |||
| Flutemetamol F-18 | 185 MBq (5 mCi) | Color scale: rainbow or Sokoloff; color scale is adjusted to set pons to approximately 90% maximum intensity | 1 |
| Regions: temporal, parietal, posterior cingulate/precuneus, frontal, striatum | |||
| Florbetaben F-18 | 300 MBq (8.1 mCi) | Color scale: gray scale or inverse gray scale | 1 |
| Regions: temporal, parietal, posterior cingulate/precuneus, and frontal | |||
| Tau | |||
| Flortaucipir F-18 | 370 MBq (10 mCi) | Color scale: color scale with rapid transition between 2 distinct colors, scale being adjusted so that transition occurs at 1.65-fold threshold; neocortical activity in either hemisphere contributes to image interpretation | Positive scan shows increased neocortical activity in posterolateral temporal, occipital, or parietal/precuneus region(s), with or without frontal activity; neocortical activity in either hemisphere can contribute to identification of positive pattern (31,32) |