Optimized Results for Each Combination of 211At-Labeled Abs
| Drug combination | Total disintegrations required* | Molar activity required (GBq/mol)* |
|---|---|---|
| Ab1 | 4.3 × 108 | 1.6 × 108 |
| Ab2 | 4.5 × 108 | 1.5 × 107 |
| Ab3 | 3.7 × 108 | 4.8 × 107 |
| Ab4 | 2.7 × 108 | 6.7 × 107 |
| Ab1 + Ab2 | 4.3 × 108 | 1.6 × 106, 1.4 × 107 |
| Ab2 + Ab3 | 2.3 × 108 | 4.2 × 106, 1.4 × 107 |
| Ab3 + Ab4 | 2.7 × 108 | 1.7 × 107, 3.4 × 106 |
| Ab1 + Ab3 | 3.7 × 108 | 5.7 × 104, 4.8 × 107 |
| Ab2 + Ab4 | 3.7 × 108 | 1.2 × 107, 2.0 × 10–7 |
| Ab1 + Ab4 | 3.1 × 108 | 5.9 × 107, 3.9 × 106 |
| Ab1 + Ab2 + Ab3 | 2.3 × 108 | 0, 4.0 × 106, 1.4 × 107 |
| Ab1 + Ab3 + Ab4 | 2.3 × 108 | 6.0 × 107, 2.6 × 106, 1.3 × 106 |
| Ab1 + Ab2 + Ab4 | 2.3 × 108 | 5.3 × 107, 3.0 × 106, 9.0 × 103 |
| Ab2 + Ab3 + Ab4 | 2.3 × 108 | 4.1 × 106, 1.4 × 107, 2.5 × 104 |
| Ab1 + Ab2 + Ab3 + Ab4 | 2.0 × 108 | 4.0 × 107, 2.1 × 106, 3.8 × 106, 0 |
* Rounded to 2 significant figures.