TABLE 5.

Univariable and Multivariable Analysis of Factors Influencing PFS

Characteristic	Univariable		Multivariable
Characteristic	HR (95% CI)	P	HR (95% CI)	P
Age at diagnosis > 60 y	2.293 (1.414–3.720)	<0.0001
Female	0.859 (0.586–1.260)	0.4367
WHO PS > 1	4.185 (2.736–6.402)	<0.0001	2.836 (1.771–4.543)	<0.0001
LDH elevated	2.413 (1.644–3.540)	<0.0001	1.713 (1.009–2.671)	0.0174
Number of extranodal sites > 1	2.307 (1.591–3.345)	<0.0001
Ann Arbor stage III–IV	2.087 (1.379–3.157)	0.0005
IPI^*		<0.0001
Low–intermediate	2.057 (1.127–3.755)	0.0189
High–intermediate	2.418 (1.317–4.441)	0.0044
High	7.077 (4.123–12.145)	<0.0001
R-IPI^†		<0.0001
Good	2.920 (0.904–9.431)	0.0732
Poor	7.521 (2.364–23.922)	0.0006
CNS invasion	2.832 (1.043–7.685)	0.0410	3.347 (1.202–9.316)	0.0207
First-line treatment^‡		<0.0001
None	17.646 (10.154–30.667)	<0.0001
Platinum-based	9.847 (3.062–31.661)	0.0001
Radiotherapy	7.866 (3.166–19.545)	<0.0001
Other	1.253 (0.508–3.091)	0.6224
SUV_max^§	1.016 (0.998–1.034)	0.0891
SUV_peak^§	1.018 (0.999–1.038)	0.0639
SUV_mean^§	0.984 (0.928–1.044)	0.5987
TVSR^§	0.965 (0.762–1.222)	0.7653
MTV (cutoff 135 cm³)	2.710 (1.747–4.204)	<0.0001
MTV (continuous)^ǁ	1.861 (1.439–2.406)	<0.0001
TLG (cutoff 1,280 g)	2.492 (1.632–3.805)	<0.0001
Dmax (cutoff 20 cm)	2.543 (1.687–3.833)	<0.0001
SDmax (cutoff 10 cm)	2.529 (1.677–3.812)	<0.0001
IMPI^¶	1.412 (1.263–1.578)	<0.0001	1.207 (1.048–1.389)	0.0089

↵* Reference: IPI low.
↵† Reference: R-IPI very good.
↵‡ Reference: R-CHOP or R-mini-CHOP.
↵§ Per unit increase.
↵ǁ Per ×10 unit increase.
↵¶ Per 10% increased risk of relapse.
HR = hazard ratio; LDH = lactate dehydrogenase; TLG = total lesion glycolysis.