Patient Characteristics (n = 355)
| Parameter | N (%) |
|---|---|
| Median age at diagnosis (y) | 69 (IQR, 58–76) |
| ≤60 y | 107 (30.1) |
| >60 y | 248 (69.9) |
| Sex | |
| Female | 144 (40.6) |
| Male | 211 (59.4) |
| WHO PS | |
| 0 | 117 (33.0) |
| 1 | 194 (54.7) |
| 2 | 31 (8.7) |
| 3 | 13 (3.7) |
| Number of extranodal sites | |
| ≤1 | 243 (68.5) |
| >1 | 112 (31.6) |
| LDH | |
| Normal | 196 (55.5) |
| Elevated | 157 (44.5) |
| Unknown | 2 |
| Ann Arbor stage | |
| I | 66 (18.6) |
| II | 78 (22.0) |
| III | 40 (11.3) |
| IV | 171 (48.2) |
| CNS invasion at diagnosis | 6 (1.7) |
| IPI | |
| Low | 128 (36.3) |
| Low–intermediate | 83 (23.5) |
| High–intermediate | 73 (20.7) |
| High | 69 (19.6) |
| Unknown | 2 |
| R-IPI | |
| Very good | 35 (9.9) |
| Good | 176 (49.7) |
| Poor | 143 (40.4) |
| Unknown | 1 |
| First-line treatment | |
| R-CHOP or R-mini-CHOP | 315 (88.7) |
| Platinum-based | 2 (0.6) |
| Noncurative radiotherapy | 6 (1.7) |
| Best supportive care | 16 (4.5) |
| Other | 16 (4.5) |
IQR = interquartile range; LDH = serum lactate dehydrogenase at diagnosis; CNS = central nervous system.