Clinical Scenarios for Diagnosis of FUO (Tables 3 and 5 in Final Published AUC)
Scenario number | Description | Appropriateness | Score* |
---|---|---|---|
In adults | |||
1 | Labeled leukocyte scintigraphy | May be appropriate | 4 |
2 | 67Ga scintigraphy | May be appropriate | 5 |
3 | 18F-FDG PET and PET/CT | Appropriate | 8 |
In children | |||
4 | Labeled leukocyte scintigraphy | Rarely appropriate | 3 |
5 | 67Ga scintigraphy | Rarely appropriate | 3 |
6 | 18F-FDG PET and PET/CT | Appropriate | 8 |
↵* The work group scored each indication as “appropriate,” “may be appropriate,” or “rarely appropriate” on a scale from 1 to 9: 7–9 = use of the procedure is appropriate for the specific clinical indication and is generally considered acceptable; 4–6 = use of the procedure may be appropriate for the specific indication, implying that more research is needed to classify the indication definitively; and 1–3 = use of the procedure is rarely appropriate for the specific indication and generally is not considered acceptable. Division of these scores into 3 general levels of appropriateness is partially arbitrary, and the numeric designations should be viewed as a continuum. When clinical opinion in the work group differed without agreement on a common score, that indication was given a “may be appropriate” rating to indicate a lack of agreement on appropriateness based on the available literature and the members’ collective clinical opinion, suggesting the need for additional research.