TABLE 1.

Structure–Activity Relationships of Quinazolinone Derivatives

Compound	IC₅₀ (nM)	pIC₅₀^*	cLog D_7.4^†
4a	353.1		−0.08
4b	19.8	7.72 ± 0.11	0.74
5a	40.1	7.43 ± 0.17	0.89
5b	2.3	8.65 ± 0.03	1.76
7a	17.6	7.76 ± 0.05	1.55
7b (LCE470)	0.33	9.49 ± 0.09	2.53

↵* Mean value ± SEM.
↵† Calculated using ACD/Labs software.
IC₅₀ = half-maximum inhibitory concentration; pIC₅₀ = negative log of the IC₅₀ value in molar concentration; cLog D_7.4 = calculated log distribution coefficient.